博来霉素

Also known as BLM, Bleocin, Bleomicin

Bleomycin is a medication primarily used to treat cancer. This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others. Typically used with other cancer medications, it can be given intravenously, by injection into a muscle or under the skin. It may also be administered inside the chest to help prevent the recurrence of a pleural effusion due to cancer; however, talc is better for this. It may sometimes be used to treat other difficult-to-treat skin lesions such as plantar warts in immunocompromised patients.

In the Vinony graph

Vinony's link graph records 396 inbound references to 博来霉素, and connects out to Hodgkin lymphoma, non-Hodgkin lymphoma and tiazofurin.

It is catalogued under topics including Cancer treatments, Chemical articles with multiple CAS registry numbers and Chemicals using indexlabels.

Vinony links it to 28 Wikipedia language editions.

Medication

Drug class: Other cytotoxic antibiotics
Active ingredients: bleomycin
Dosage form: Injection

Sources: openFDA · RxNorm (NLM). Not medical advice.

Research

25,090 papers

Bleomycin.Cancer chemotherapy and biological response modifiers · 1994
Bleomycin.Cancer chemotherapy and biological response modifiers · 1997
Bleomycin.Cancer chemotherapy and biological response modifiers · 1999
Bleomycin-induced pulmonary toxicity in chemotherapy for testicular cancer.Expert opinion on drug safety · 2003
A systematic review of bleomycin-induced gonadotoxicity: Mechanistic implications for male reproductive health and fertility.Reproductive toxicology (Elmsford, N.Y.) · 2024

via PubMed

Clinical Trials

91 registered

PHASE3RECRUITING
TC or BEP in Treating Patients With Ovarian Malignant Sex Cord-Stromal TumorsBeihua Kong · NCT02429700
PHASE2NOT_YET_RECRUITING
Injection Sclerotherapy With Bleomycin VS Doxycycline in Patients With Lymphatic MalformationsBasharat Hussain · NCT07320001
NAENROLLING_BY_INVITATION
TACE Treats Nodular GoiterPeking Union Medical College Hospital · NCT07258199
PHASE4COMPLETED
Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural EffusionMohamed Sabry · NCT06744946
PHASE4WITHDRAWN
Pharmacokinetic Study of Aprepitant in BEP Treatment of Patients With Testis Carcinoma (A-BEP)Radboud University Medical Center · NCT00429754
PHASE2COMPLETED
Intralesional Bleomycin Versus Cryotherapy for Treatment of Cutaneous WartsJinnah Postgraduate Medical Centre · NCT05023408

via ClinicalTrials.gov

Wikidata facts

Instance of: mixture
Manufacturer: Pfizer
Image: Bleomycin ball-and-stick.png

Show 7 more facts

World Health Organisation international non-proprietary name: bleomycin
medical condition treated: melanoma
Commons category: Bleomycins
subject has role: antibiotic
chemical formula: C₅₅H₈₄N₁₇O₂₁S₃⁺
legal status (medicine): boxed warning
significant drug interaction: brentuximab vedotin

Sources (5)

via Wikidata · CC0

Article · 中文

博来霉素（Bleomycin，又名博莱霉素、争光霉素）是用於治療癌症的藥物。治療範圍包含霍奇金氏淋巴瘤、非霍奇金氏淋巴瘤、睪丸癌、卵巢癌及子宮頸癌等，有時也被外用于疣，及用于胸膜粘连术。通常會與其他癌症化療藥物一起使用。它可以靜脈注射、肌肉注射，或是從皮下注射。也可以用於胸腔，以防止癌症引起的復發，然而滑石粉對此有更好的效果。常見副作用包含發燒、體重減輕、嘔吐和起皮疹，可能發生嚴重的過敏反應。它也可能引起，導致肺纖維化，因此建議每隔幾週就使用胸部X光進行檢查。如果在懷孕期間使用博來黴素，可能會對胎兒造成傷害。此藥物被認為透過和DNA結合而起作用。博來黴素提煉自（Streptomyces verticillus）产生的糖肽类，於1962年被發現。本品列名於世界衛生組織的基本藥物清單中，是對於基礎公衛體系必備藥物之一，本品屬於學名藥。每劑的批發價約介於14至78美元之間。

Abstract from DBpedia / Wikipedia · CC BY-SA