博来霉素
Sign in to saveAlso known as BLM, Bleocin, Bleomicin
Bleomycin is a medication primarily used to treat cancer. This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others. Typically used with other cancer medications, it can be given intravenously, by injection into a muscle or under the skin. It may also be administered inside the chest to help prevent the recurrence of a pleural effusion due to cancer; however, talc is better for this. It may sometimes be used to treat other difficult-to-treat skin lesions such as plantar warts in immunocompromised patients.
Medication
- Drug class
- Other cytotoxic antibiotics
- Active ingredients
- bleomycin
- Dosage form
- Injection
Research
25,090 papers- Bleomycin.Cancer chemotherapy and biological response modifiers · 1994
- Bleomycin.Cancer chemotherapy and biological response modifiers · 1997
- Bleomycin.Cancer chemotherapy and biological response modifiers · 1999
- Bleomycin-induced pulmonary toxicity in chemotherapy for testicular cancer.Expert opinion on drug safety · 2003
- A systematic review of bleomycin-induced gonadotoxicity: Mechanistic implications for male reproductive health and fertility.Reproductive toxicology (Elmsford, N.Y.) · 2024
via PubMed
Clinical Trials
91 registered- PHASE3RECRUITINGTC or BEP in Treating Patients With Ovarian Malignant Sex Cord-Stromal TumorsBeihua Kong · NCT02429700
- PHASE2NOT_YET_RECRUITINGInjection Sclerotherapy With Bleomycin VS Doxycycline in Patients With Lymphatic MalformationsBasharat Hussain · NCT07320001
- NAENROLLING_BY_INVITATIONTACE Treats Nodular GoiterPeking Union Medical College Hospital · NCT07258199
- PHASE4COMPLETEDThoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural EffusionMohamed Sabry · NCT06744946
- PHASE4WITHDRAWNPharmacokinetic Study of Aprepitant in BEP Treatment of Patients With Testis Carcinoma (A-BEP)Radboud University Medical Center · NCT00429754
- PHASE2COMPLETEDIntralesional Bleomycin Versus Cryotherapy for Treatment of Cutaneous WartsJinnah Postgraduate Medical Centre · NCT05023408
Wikidata facts
Show 7 more facts
- World Health Organisation international non-proprietary name
- bleomycin
- medical condition treated
- melanoma
- Commons category
- Bleomycins
- subject has role
- antibiotic
- chemical formula
- C₅₅H₈₄N₁₇O₂₁S₃⁺
- legal status (medicine)
- boxed warning
- significant drug interaction
- brentuximab vedotin
via Wikidata · CC0
Article · 中文
博来霉素（Bleomycin，又名博莱霉素、争光霉素）是用於治療癌症的藥物。治療範圍包含霍奇金氏淋巴瘤、非霍奇金氏淋巴瘤、睪丸癌、卵巢癌及子宮頸癌等，有時也被外用于疣，及用于胸膜粘连术。通常會與其他癌症化療藥物一起使用。它可以靜脈注射、肌肉注射，或是從皮下注射。也可以用於胸腔，以防止癌症引起的復發，然而滑石粉對此有更好的效果。 常見副作用包含發燒、體重減輕、嘔吐和起皮疹，可能發生嚴重的過敏反應。它也可能引起，導致肺纖維化，因此建議每隔幾週就使用胸部X光進行檢查。如果在懷孕期間使用博來黴素，可能會對胎兒造成傷害。此藥物被認為透過和DNA結合而起作用。 博來黴素提煉自（Streptomyces verticillus）产生的糖肽类，於1962年被發現。本品列名於世界衛生組織的基本藥物清單中，是對於基礎公衛體系必備藥物之一，本品屬於學名藥。每劑的批發價約介於14至78美元之間。
Abstract from DBpedia / Wikipedia · CC BY-SA