broxaterol
Sign in to saveBroxaterol is a β2 adrenoreceptor agonist. It is part of a class of drugs that affect the smooth muscle receptors in the body, often in use cases for respiratory disease that respond to this type of treatment.
Chemical data
- Formula
- C9H15BrN2O2
- Molecular weight
- 263.13 g/mol
- IUPAC name
- 1-(3-bromo-1,2-oxazol-5-yl)-2-(tert-butylamino)ethanol
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Research
47 papers- Broxaterol: pharmacological profile of a unique structural feature.Respiration; international review of thoracic diseases · 1989
- Broxaterol: therapeutic trials and safety profile.Respiration; international review of thoracic diseases · 1989
- Role of broxaterol in bronchial hyperresponsiveness.Respiration; international review of thoracic diseases · 1989
- Broxaterol increases force output of fatigued canine diaphragm more than salbutamol.American journal of respiratory and critical care medicine · 1997
- Effects of intravenous broxaterol on respiratory drive and neuromuscular coupling in COPD patients.The European respiratory journal · 1993
via PubMed
Article
2 sectionsContents
- Synthesis
- References
Broxaterol is a β2 adrenoreceptor agonist. It is part of a class of drugs that affect the smooth muscle receptors in the body, often in use cases for respiratory disease that respond to this type of treatment.
==Synthesis== upright=2 The 1,3-dipolar cycloaddition between bromonitrile oxide, produced in situ from dibromoformaldoxime, and 3-butyn-2-one gives a mixture of isoxazoles, mainly the isomer shown required for broxaterol. Selective α-bromination of the acetyl group with pyridinium tribromide gives a bromoketone whose carbonyl group is reduced with sodium borohydride to produce a bromoethanol derivative. Treatment of this with tert-butylamine yields broxaterol.