Structure via PubChem · Public domain (PubChem)
busulfan
Sign in to saveAlso known as Busulfex IV®, Myleran®, Tetramethylene bis(methanesulfonate), 1,4-Dimesyloxybutane, 1,4-Bis(methanesulfonoxy)butane, 1,4-Dimethanesulfonoxybutane, 1,4-Butanediol dimethanesulfonate
Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is 1,4-butanediol dimethanesulfonate.
Chemical data
- Formula
- C6H14O6S2
- Molecular weight
- 246.3 g/mol
- IUPAC name
- 4-methylsulfonyloxybutyl methanesulfonate
- SMILES
- CS(=O)(=O)OCCCCOS(=O)(=O)C
- InChIKey
- COVZYZSDYWQREU-UHFFFAOYSA-N
- XLogP
- -0.5
- Polar surface area
- 104 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
7,971 papers- Busulfan.The Annals of pharmacotherapy · 1994
- Busulfan.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses · 1996
- Busulfan in hematopoietic stem cell transplant setting.Expert opinion on drug metabolism & toxicology · 2009
- Proteomic analysis for busulfan-induced spermatogenesis disorder.Annals of medicine · 2025
- Busulfan use in hematopoietic stem cell transplantation: pharmacology, dose adjustment, safety and efficacy in adults and children.Current drug safety · 2008
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 246.02318
- Manufacturer
- Pfizer
- Has use
- medication
Show 7 more facts
- chemical formula
- C₆H₁₄O₆S₂
- canonical SMILES
- CS(=O)(=O)OCCCCOS(=O)(=O)C
- medical condition treated
- acute myeloid leukemia
- World Health Organisation international non-proprietary name
- busulfan
- Commons category
- Busulfan
- melting point
- 115.5
- legal status (medicine)
- boxed warning
Sources (7)
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- History
- Indications
- Availability
- Side effects
- Dosing, administration, and pharmacokinetics
- Drug interactions
- Pharmacology
- Complexation
- References
- External links
Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is 1,4-butanediol dimethanesulfonate.
==History== Busulfan was approved by the US Food and Drug Administration (FDA) for treatment of chronic myeloid leukemia (CML) in 1999. Busulfan was the mainstay of the chemotherapeutic treatment of chronic myeloid leukemia (CML) until it was displaced by the new gold standard, imatinib, though it is still in use to a degree as a result of the drug's relative low cost.
Excerpted from Wikipedia’s “busulfan” article, available under the CC BY-SA 4.0 licence.