butriptyline
Sign in to saveAlso known as (±)-3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-yl)-N,N,2-trimethylpropan-1-amine
Butriptyline, sold under the brand name Evadyne among others, is a tricyclic antidepressant (TCA) that has been used in the United Kingdom and several other European countries for the treatment of depression but appears to no longer be marketed. Along with trimipramine, iprindole, and amoxapine, it has been described as an "atypical" or "second-generation" TCA due to its relatively late introduction and atypical pharmacology. It was very little-used compared to other TCAs, with the number of prescriptions dispensed only in the thousands.
Research
59 papers- A double-blind controlled multicenter trial comparing butriptyline with amitriptyline.Neuropsychobiology · 1983
- Comparative pharmacological studies on butriptyline and some related standard tricyclic antidepressants.Canadian journal of physiology and pharmacology · 1975
- Butriptyline: human pharmacokinetics and comparative bioavailability of conventional and sustained release formulations.Biopharmaceutics & drug disposition · 1981
- Clinical trials with butriptyline.Journal of medicine · 1971
- ECG changes on butriptyline.Communications in psychopharmacology · 1979
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 293.214
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₁H₂₇N
- canonical SMILES
- CC(CC1C2=CC=CC=C2CCC3=CC=CC=C13)CN(C)C
- defined daily dose
- 75
- subject has role
- anxiolytic
- Commons category
- Butriptyline
Sources (3)
via Wikidata · CC0
~5 min read
Encyclopedic overview
13 sectionsContents
- Medical uses
- Side effects
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- References
Butriptyline, sold under the brand name Evadyne among others, is a tricyclic antidepressant (TCA) that has been used in the United Kingdom and several other European countries for the treatment of depression but appears to no longer be marketed. Along with trimipramine, iprindole, and amoxapine, it has been described as an "atypical" or "second-generation" TCA due to its relatively late introduction and atypical pharmacology. It was very little-used compared to other TCAs, with the number of prescriptions dispensed only in the thousands.
==Medical uses== Butriptyline was used in the treatment of depression. It was usually used at dosages of 150–300 mg/day.
Excerpted from Wikipedia’s “butriptyline” article, available under the CC BY-SA 4.0 licence.