carbenoxolone
Sign in to saveCarbenoxolone (CBX) is a glycyrrhetinic acid derivative with a steroid-like structure, similar to substances found in the root of the licorice plant. Carbenoxolone is used for the treatment of peptic, esophageal and oral ulceration and inflammation. Electrolyte imbalance is a serious side effect of carbenoxolone when used systemically.
Research
1,881 papers- Analgesic and anti-inflammatory properties of carbenoxolone: a review.Inflammopharmacology · 2025
- Carbenoxolone disodium suppresses the migration of gastric cancer by targeting HDAC6.Future medicinal chemistry · 2023
- Carbenoxolone: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease.Drugs · 1976
- Systematic review of neurological diseases and carbenoxolone: A double-edged sword?European journal of pharmacology · 2025
- Carbenoxolone Ameliorates Allergic Airway Inflammation through NF-κB/NLRP3 Pathway in Mice.Biological & pharmaceutical bulletin · 2022
via PubMed
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Encyclopedic overview
3 sectionsContents
- Nootropic effects
- See also
- References
Carbenoxolone (CBX) is a glycyrrhetinic acid derivative with a steroid-like structure, similar to substances found in the root of the licorice plant. Carbenoxolone is used for the treatment of peptic, esophageal and oral ulceration and inflammation. Electrolyte imbalance is a serious side effect of carbenoxolone when used systemically.
Carbenoxolone reversibly inhibits the conversion of inactive cortisone to cortisol by blocking 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-HSD also reversibly catalyzes the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol.
Excerpted from Wikipedia’s “carbenoxolone” article, available under the CC BY-SA 4.0 licence.
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