cefteram

Cefteram (INN) is a third-generation cephalosporin antibiotic. ==Synthesis== upright=2 The reaction of 7-aminocephalosporanic acid (1) with the methyl-substituted tetrazole (2) gives the intermediate (3). Protection with diazodiphenylmethane (4) produces (5). Amide formation with the thiazole carboxylic acid (6) gives (7), which is deprotected with trifluoroacetic acid to yield cefteram.

In the Vinony graph

Vinony's link graph records 186 inbound references to cefteram, and connects out to antibiotic, ceftolozane/tazobactam and penicillin.

It is catalogued under topics including Cephalosporin antibiotics, Chemical pages without DrugBank identifier and Drugs with non-standard legal status.

Vinony links it to 8 Wikipedia language editions.

Chemical data

Formula: C16H17N9O5S2
Molecular weight: 479.5 g/mol
IUPAC name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SMILES: CC1=NN(N=N1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)O
InChIKey: XSPUSVIQHBDITA-RKYNPMAHSA-N
XLogP: -0.9
Polar surface area: 244 Å²
H-bond donors: 3
H-bond acceptors: 13
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: bacterial disease

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 479.0794066440001

Show 4 more facts

Commons category: Cefteram
chemical formula: C₁₆H₁₇N₉O₅S₂
isomeric SMILES: Cc1nnn(n1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=NOC)/c4csc(n4)N)SC2)C(=O)O
canonical SMILES: CC1=NN(N=N1)CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O

Sources (2)

via Wikidata · CC0

~1 min read