celiprolol

Also known as REV 5320, ST-1396, ST1396, (RS)-N'-{3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-N,N-diethylurea

Celiprolol is a medication in the class of beta blockers, used in the treatment of high blood pressure. It has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. It is also a weak α2 receptor antagonist.

Key facts

Drug.PubChem: 2663
Drug.IUPAC_name: (RS)-N'-{3-Acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-N,N-diethylurea
Drug.image: Celiprolol.svg
Drug.image_class: skin-invert-image
Drug.width: 200px
Drug.chirality: Racemic mixture
Drug.bioavailability: 30-70%
Drug.elimination_half life: 5 hours
Drug.CAS_number: 56980-93-9
Drug.ATC_prefix: C07
Drug.ATC_suffix: AB08
Drug.DrugBank: DB04846
Drug.ChemSpiderID: 2563
Drug.UNII: DRB57K47QC
Drug.KEGG: D07660
Drug.ChEMBL: 27810
Drug.C: 20
Drug.H: 33

via Wikipedia infobox

Research

550 papers

Celiprolol pneumonitis.The European respiratory journal · 1993
The Impact of Celiprolol in Vascular Ehlers-Danlos Syndrome: A Systematic Review of Current Evidence.Medical sciences (Basel, Switzerland) · 2025
Celiprolol in hypertension.American heart journal · 1988
Celiprolol and sympatho-immune interface in COVID-19.Immunology · 2023
Celiprolol--a better beta blocker?Drug and therapeutics bulletin · 1992

via PubMed

Wikidata facts

Mass: 379.247

Show 4 more facts

chemical formula: C₂₀H₃₃N₃O₄
World Health Organisation international non-proprietary name: celiprolol
canonical SMILES: CCN(CC)C(=O)NC1=CC(=C(C=C1)OCC(CNC(C)(C)C)O)C(=O)C
defined daily dose: 0.2

Sources (4)

via Wikidata · CC0

~2 min read

Article

4 sections

Contents

Medical use
Brand names
References
External links

{{Infobox drug | IUPAC_name = (RS)-N'-{3-Acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-N,N-diethylurea | image = Celiprolol.svg | image_class = skin-invert-image | width = 200px | chirality = Racemic mixture