cetilistat
Sign in to saveAlso known as Cetilistat/ATL-962
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
Research
32 papers- Cetilistat, a new lipase inhibitor for the treatment of obesity.Current opinion in investigational drugs (London, England : 2000) · 2008
- Cetilistat for the treatment of obesity.Drugs of today (Barcelona, Spain : 1998) · 2013
- Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2008
- Repurposing FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, and remdesivir as potential inhibitors against RNA dependent RNA polymerase of SARS-CoV-2: A comparative in silico perspective.Informatics in medicine unlocked · 2023
- Novel method to prevent severe postoperative pancreatic fistula caused by lipolysis.Journal of hepato-biliary-pancreatic sciences · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 401.293
Show 2 more facts
- chemical formula
- C₂₅H₃₉NO₃
- canonical SMILES
- CCCCCCCCCCCCCCCCOC1=NC2=C(C=C(C=C2)C)C(=O)O1
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
2 sectionsContents
- See also
- References
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
In human trials from 2007, cetilistat was shown to produce similar weight loss to orlistat, but also produced similar side effects such as oily, loose stools, fecal incontinence, frequent bowel movements, and flatulence. It is likely that the same precautions would apply in that absorption of fat-soluble vitamins and other fat-soluble nutrients may be inhibited, requiring vitamin supplements to be used to avoid deficiencies.
Excerpted from Wikipedia’s “cetilistat” article, available under the CC BY-SA 4.0 licence.