CFL2
Sign in to saveAlso known as NEM7, cofilin 2
Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.
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Within Vinony's link graph, CFL2 is referenced by 275 other articles, and connects out to hair keratin, PubMed and human chromosome 14.
It is catalogued under the topic Genes on human chromosome 14.
Its subject is documented across 5 Wikipedia language editions.
Gene data
CFL2- Name
- cofilin 2
- Type
- protein-coding
- Position
- 34,707,001–34,714,946 (−)
- Aliases
- NEM7
- Ensembl
- ENSG00000165410
- RefSeq RNA
- NM_001243645.2, NM_021914.8, NM_138638.5, NR_028130.2, NR_028131.2
- RefSeq protein
- NP_001230574.1, NP_068733.1, NP_619579.1
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cofilin 2
- Symbol
- CFL2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:34,707,001-34,714,946
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- PDB 1tvj EBI.png
Show 7 more facts
- HomoloGene ID
- 129115
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1073
- genomic end
- 35184029
- genomic start
- 34709113
- chromosome
- human chromosome 14
- cytogenetic location
- 14q13.1
Sources (7)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- References
- External links
- Further reading
Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.
==Function== Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN), all of which regulate actin-filament dynamics. The CFL2 gene encodes a skeletal muscle-specific isoform localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins.
Excerpted from Wikipedia’s “CFL2” article, available under the CC BY-SA 4.0 licence.