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Structure via PubChem · Public domain (PubChem)
chlordiazepam
Sign in to saveAlso known as 4'-chlorodiazepam
Ro5-4864 ('''4'-chlorodiazepam') is a drug which is a benzodiazepine derivative of diazepam. However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects. Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor", later renamed to mitochondrial translocator protein 18kDa (TSPO). Despite its convulsant effects, at lower doses Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the
Chemical data
- Formula
- C16H12Cl2N2O
- Molecular weight
- 319.2 g/mol
- IUPAC name
- 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
637 papers- Neurosteroid coadministration prevents development of tolerance and augments recovery from benzodiazepine withdrawal anxiety and hyperactivity in mice.Methods and findings in experimental and clinical pharmacology · 1997
- Effects of a peripheral-type benzodiazepine on glucose-induced insulin secretion.European journal of pharmacology · 1992
- [Research of the mechanism of the inhibition of insulin secretion induced by a peripheral benzodiazepine: 4'-chlordiazepam].Comptes rendus des seances de la Societe de biologie et de ses filiales · 1993
- Effects of 4'-chlordiazepam on glycemia and serum lipids in hyperlipidemic rats: interactions with PK 11195 and flumazenil.Research communications in molecular pathology and pharmacology · 1995
- Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors.Behavioral and neural biology · 1990
via PubMed
Wikidata facts
- Mass
- 318.033
Show 3 more facts
- chemical formula
- C₁₆H₁₂Cl₂N₂O
- canonical SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=C(C=C3)Cl
- Commons category
- Ro5-4864
Sources (2)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- See also
- References
Ro5-4864 ('''4'-chlorodiazepam') is a drug which is a benzodiazepine derivative of diazepam. However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects. Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor", later renamed to mitochondrial translocator protein 18kDa (TSPO). Despite its convulsant effects, at lower doses Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity. In vitro'' studies and rodent models also suggest the possibility of analgesic, antidepressant, cardioprotective, and anti-cancer effects.
== See also == 4'-Chlorodeschloroalprazolam Diclazepam (2'-chlorodiazepam) PK-11195