chloropyramine
Sign in to saveAlso known as Halopyramine, Chlorpyramine, SID50100492, SID11112580
Chloropyramine is a first-generation antihistamine drug approved in several Eastern European countries such as Russia for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Related indications for clinical use include angioedema, allergic reactions to insect bites, food and drug allergies, and anaphylactic shock.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.class
- First-generation antihistamine
- Drug.verifiedrevid
- 447430568
- Drug.IUPAC_name
- ''N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'''-pyridin-2-ylethane-1,2-diamine
- Drug.image
- Chloropyramine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.pregnancy_category
- C
- Drug.legal_status
- By mouth: OTC, Injection: Rx-only (RU)
- Drug.routes_of_administration
- By mouth, intramuscular, topical
- Drug.bioavailability
- ~100%
- Drug.metabolism
- Extensive hepatic
- Drug.onset
- 15–30 min (oral)
- Drug.elimination_half life
- ~14 hours
- Drug.excretion
- Kidney
- Drug.CAS_number
- 59-32-5
- Drug.ATC_prefix
- D04
via Wikipedia infobox
Research
93 papers- Suprastin (Chloropyramine) Causes Proarrhythmic Deterioration of Excitation Conduction, Depolarization and Potentiates Adrenergic Automaticity in the Pulmonary Veins Myocardium.Bulletin of experimental biology and medicine · 2024
- Discovery of novel chloropyramine-cinnamic acid hybrids as potential FAK inhibitors for intervention of metastatic triple-negative breast cancer.Bioorganic & medicinal chemistry · 2022
- Possible teratogenicity of imipramine-chloropyramine.Lancet (London, England) · 1973
- Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.Journal of medicinal chemistry · 2009
- Effects of chloropyramine and famotidine on postischaemic and posthypoxic myocardial damage in isolated rat hearts.Pflugers Archiv : European journal of physiology · 1996
via PubMed
Wikidata facts
- Mass
- 289.135
Show 4 more facts
- chemical formula
- C₁₆H₂₀ClN₃
- canonical SMILES
- CN(C)CCN(CC1=CC=C(C=C1)Cl)C2=CC=CC=N2
- defined daily dose
- 20
- Commons category
- Chloropyramine
via Wikidata · CC0
~4 min read
Article
8 sectionsContents
- Contraindications
- Adverse effects
- Interactions
- Dosage
- Trade names
- Synthesis
- See also
- References
Chloropyramine is a first-generation antihistamine drug approved in several Eastern European countries such as Russia for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Related indications for clinical use include angioedema, allergic reactions to insect bites, food and drug allergies, and anaphylactic shock.
Chloropyramine is known as a competitive reversible H1 receptor antagonist (also known as an H1 inverse agonist), meaning that it exerts its pharmacological action by competing with histamine for the H1 subtype histamine receptor. By blocking the effects of histamine, the drug inhibits the vasodilation, increased vascular permeability, and tissue edema associated with histamine release in the tissue. The H1 antagonistic properties of chloropyramine can be used by researchers for the purposes of blocking the effects of histamine on cells and tissues. In addition, chloropyramine has some anticholinergic properties.
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