Structure via PubChem · Public domain (PubChem)
chlorpheniramine
Sign in to saveAlso known as Phenetron®, Teldrin®, chlorophenylpyridamine, gamma-(4-chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine, 3-(p-chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine, 1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine, 1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane, gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
Chlorphenamine (CP, CPM), also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis (hay fever). It is taken orally (by mouth). The medication takes effect within two hours and lasts for about 4–6 hours. It is a first-generation antihistamine and works by blocking the histamine H1 receptor.
Chemical data
- Formula
- C16H19ClN2
- Molecular weight
- 274.79 g/mol
- IUPAC name
- 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
- SMILES
- CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
- InChIKey
- SOYKEARSMXGVTM-UHFFFAOYSA-N
- XLogP
- 3.4
- Polar surface area
- 16.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
3,078 papers- Clinical pharmacokinetics of chlorpheniramine.Drug intelligence & clinical pharmacy · 1984
- Chlorpheniramine produces cutaneous analgesia in rats.Pharmacological reports : PR · 2020
- Chlorpheniramine poisoning as a potential cause of rhabdomyolysis.The American journal of emergency medicine · 2022
- Chlorpheniramine-dependent thrombocytopenia.JAMA · 1975
- Hydrocodone/chlorpheniramine (Vituz).The Medical letter on drugs and therapeutics · 2013
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 274.124
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₆H₁₉ClN₂
- canonical SMILES
- CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
- Commons category
- Chlorphenamine
- medical condition treated
- urticaria
- physically interacts with
- Histamine receptor H1
- has characteristic
- bitterness
- defined daily dose
- 12
- significant drug interaction
- alfentanil
via Wikidata · CC0
~7 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Combination products
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- Society and culture
- Names
- References
Chlorphenamine (CP, CPM), also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis (hay fever). It is taken orally (by mouth). The medication takes effect within two hours and lasts for about 4–6 hours. It is a first-generation antihistamine and works by blocking the histamine H1 receptor.
Common side effects include sleepiness, restlessness, and weakness. Other side effects may include dry mouth and wheeziness.
Excerpted from Wikipedia’s “chlorpheniramine” article, available under the CC BY-SA 4.0 licence.