CLDN18
Sign in to saveAlso known as SFTA5, SFTPJ, claudin 18
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.
Gene data
CLDN18- Name
- claudin 18
- Type
- protein-coding
- Aliases
- SFTA5, SFTPJ
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9489
- exact match
- identifiers.org/ncbigene/51208
- genomic end
- 137752494
- genomic start
- 137717577
- cytogenetic location
- 3q22.3
Sources (3)
via Wikidata · CC0
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Article
4 sectionsContents
- Clinical significance
- References
- External links
- Further reading
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells . [supplied by OMIM]