Structure via PubChem · Public domain (PubChem)
clobetasol
Sign in to saveAlso known as (11beta,16beta)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison.
Chemical data
- Formula
- C22H28ClFO4
- Molecular weight
- 410.9 g/mol
- IUPAC name
- (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- SMILES
- C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C
- InChIKey
- FCSHDIVRCWTZOX-DVTGEIKXSA-N
- XLogP
- 2.5
- Polar surface area
- 74.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- Vulvar Lichen Sclerosus, psoriasis, toxic epidermal necrolysis, bullous pemphigoid
via ChEMBL · EBI
Research
2,332 papers- Clobetasol propionate foam, 0.05%.American journal of clinical dermatology · 2001
- Clobetasol propionate--where, when, why?Drugs of today (Barcelona, Spain : 1998) · 2008
- Clobetasol propionate for psoriasis: are ointments really more potent?Journal of drugs in dermatology : JDD · 2006
- Clobetasol propionate foam in the treatment of psoriasis.Expert opinion on pharmacotherapy · 2005
- Clobetasol-induced milia.Journal of the American Academy of Dermatology · 1989
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 410.166
Show 7 more facts
- route of administration
- topical medication
- chemical formula
- C₂₂H₂₈ClFO₄
- isomeric SMILES
- C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C
- canonical SMILES
- CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)O)C)O)F)C
- World Health Organisation international non-proprietary name
- 氯倍他索
- subject has role
- glucocorticoid
- Commons category
- Clobetasol
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison.
==References==
Excerpted from Wikipedia’s “clobetasol” article, available under the CC BY-SA 4.0 licence.