factor de coagulación X
Sign in to saveAlso known as factor Xa, Stuart-Prower factor, factor X, prothrombinase, F10, Stuart factor
mammalian protein found in Homo sapiens
Protein · UniProt
Coagulation factor X
- Gene
- F10
- Organism
- Homo sapiens (Human)
- Length
- 488 aa
- Molecular mass
- 54,732 Da
- Evidence
- 1: Evidence at protein level
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed:22409427, PubMed:39880037). Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (PubMed:24041930, PubMed:30568593, PubMed:34831181, PubMed:18202198). Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells (PubMed:35738824). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CC…
Swiss-Prot (reviewed) · via UniProt
Research
11,356 papers- Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics.Journal of thrombosis and thrombolysis · 2021
- Factor X Friuli Coagulation Disorder: Almost 50 Years Later.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018
- Autoimmune Coagulation Factor X Deficiency as a Rare Acquired Hemorrhagic Disorder: A Literature Review.Thrombosis and haemostasis · 2022
- Factor X deficiency.Blood reviews · 2002
- Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent.Blood cells, molecules & diseases · 2021
via PubMed
Clinical Trials
270 registered- COMPLETEDAre There Differences Between Carriers of Haemophilia A and B?Cliniques universitaires Saint-Luc- Université Catholique de Louvain · NCT05217992
- PHASE1COMPLETEDStudy of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without InhibitorsBayer · NCT01921855
- COMPLETEDStudy of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE or RIXUBISBaxalta now part of Shire · NCT02190149
- PHASE1/PHASE2COMPLETEDTrial of AAV5-hFIX in Severe or Moderately Severe Hemophilia BCSL Behring · NCT02396342
- NACOMPLETEDGene Therapy for Chinese Hemophilia BInstitute of Hematology & Blood Diseases Hospital, China · NCT04135300
- PHASE1COMPLETEDSafety and Mode of Action of a Single Dose and Multiple Doses of Long Acting Activated Recombinant Human Factor VII in Patients With Haemophilia A and BNovo Nordisk A/S · NCT00922792
Wikidata facts
- Instance of
- protein
- Image
- Protein F10 PDB 1c5m.png
Show 5 more facts
- found in taxon
- Homo sapiens
- biological process
- blood coagulation
- cell component
- extracellular space
- exact match
- purl.uniprot.org/uniprot/P00742
- physically interacts with
- edoxaban
via Wikidata · CC0
Article · Español
El factor X de la coagulación es una proteína con propiedades enzimáticas que participa en la cascada de la coagulación. También es conocida como factor Stuart Prower o autoprotrombina III. Forma parte de un grupo de enzimas conocidas como Serino proteasas, y dentro de los factores de coagulación pertenece al grupo de los , entre los que se encuentran los factores II, VII, IX y X. El Factor X es relativamente estable en suero a 37 °C y a un pH 6-9, sin embargo se inactiva rápidamente fuera de estos valores. (Platt, 1982, pág. 307) El gen que codifica para este factor se encuentra en el brazo largo del cromosoma 13 en proximidad al gen del factor VII. Este gen se expresa de manera principal en el hígado, por lo que el principal sitio de síntesis de este factor es en el hígado, desde donde pasa a la circulación general luego de ser . Tiene otras actividades biológicas que no están directamente relacionadas con la coagulación como actividades mitogénicas en células del músculo liso y posee actividades proinflamatorias mediadas por receptores.
Abstract from DBpedia / Wikipedia · CC BY-SA