Structure via PubChem · Public domain (PubChem)
سیکلوتیازید
Sign in to saveAlso known as Anhydron®, Aquirel®, 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide, 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, 6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-chloro-3,4-dihydro-3-(2-Norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide, Cyclothiazidum
Cyclothiazide (Anhydron, Acquirel, Doburil, Fluidil, Renazide, Tensodiural, Valmiran), sometimes abbreviated CTZ, is a benzothiadiazide (thiazide) diuretic and antihypertensive that was originally introduced in the United States in 1963 by Eli Lilly and was subsequently also marketed in Europe and Japan. Related drugs include diazoxide, hydrochlorothiazide, and chlorothiazide.
Chemical data
- Formula
- C14H16ClN3O4S2
- Molecular weight
- 389.9 g/mol
- IUPAC name
- 3-(2-bicyclo[2.2.1]hept-5-enyl)-6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
- SMILES
- C1C2CC(C1C=C2)C3NC4=CC(=C(C=C4S(=O)(=O)N3)S(=O)(=O)N)Cl
- InChIKey
- BOCUKUHCLICSIY-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 135 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
592 papers- [CYCLOTHIAZIDE].Meditsinskaia promyshlennost' SSSR · 1964
- Allosteric competition and inhibition in AMPA receptors.Nature structural & molecular biology · 2024
- Cyclothiazide prolongs low [Mg2+]-induced seizure-like events.Journal of neurophysiology · 2006
- Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants.Molecular pharmacology · 1994
- Cyclothiazide: a subunit-specific inhibitor of GABAC receptors.The Journal of physiology · 2008
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 389.027076
- Has use
- medication
Show 7 more facts
- medical condition treated
- arterial hypertension
- chemical formula
- C₁₄H₁₆ClN₃O₄S₂
- defined daily dose
- 5.0
- canonical SMILES
- C1C2CC(C1C=C2)C3NC4=CC(=C(C=C4S(=O)(=O)N3)S(=O)(=O)N)Cl
- subject has role
- diuretic
- World Health Organisation international non-proprietary name
- cyclothiazide
- Commons category
- Cyclothiazide
Sources (3)
via Wikidata · CC0
Gallery (2)
Available in 11 languages
via Wikidata sitelinks · CC0