darodipine
Sign in to saveDarodipine is an experimental calcium channel blocker that based on animal models may reduce neuronal cytoskeletal alterations during aging and in neurodegenerative disorders. Studies performed on rats have shown darodipine to have an effect on brain serotonergic systems. Darodipine increased the 5-HIAA/5-HT ratio within various parts of the brain. Darodipine has also been shown to impair memory and learning processes on mice.
Chemical data
- Formula
- C19H21N3O5
- Molecular weight
- 371.4 g/mol
- IUPAC name
- diethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
via PubChem
Research
87 papers- Effects of isradipine and darodipine on serotonergic system of the rat brain.Pharmacology, biochemistry, and behavior · 1995
- Protective effect of darodipine, a calcium antagonist, on rat cardiomyocytes against oxygen radical-mediated injury.British journal of pharmacology · 1997
- Comparative binding of two closely related dihydropyridines (isradipine and darodipine) to serum proteins and erythrocytes.Pharmacology · 1988
- Interactions between darodipine or isradipine and the 5-HT1A receptor agonist 8-OHDPAT in rat brain.Pharmacology, biochemistry, and behavior · 1997
- Peculiar effects of isradipine and darodipine on the rat brain dopaminergic system.General pharmacology · 1995
via PubMed
Article
3 sectionsContents
- See also
- References
- Further reading
Darodipine is an experimental calcium channel blocker that based on animal models may reduce neuronal cytoskeletal alterations during aging and in neurodegenerative disorders. Studies performed on rats have shown darodipine to have an effect on brain serotonergic systems. Darodipine increased the 5-HIAA/5-HT ratio within various parts of the brain. Darodipine has also been shown to impair memory and learning processes on mice.
The longterm effect of darodipine was tested in the rats and it shows that there is no significant change in their body and brain weight values but, there is a significant change in their alkaline phosphate reactive capillary profile values. Alkaline phosphate enzymes plays an important role in the functioning of the cerebral capillary activities. The effect of darodipine on plasma concentration was also tested on a group of healthy male human volunteers. The result showed that darodipine resulted in the change in heart rate and diastolic blood pressure which is related to the plasma concentration.