Structure via PubChem · Public domain (PubChem)
دکستیمید
Sign in to saveAlso known as (+)-benzetimide, R 16470, Tremblex®, Dexetimide
Dexetimide (brand name Tremblex) is a piperidine anticholinergic. It is a muscarinic antagonist that is used to treat drug induced parkinsonism. Dexetimide was discovered at Janssen Pharmaceutica in 1968.
Chemical data
- Formula
- C23H26N2O2
- Molecular weight
- 362.5 g/mol
- IUPAC name
- (3S)-3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione
- SMILES
- C1CN(CCC1[C@@]2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4
- InChIKey
- LQQIVYSCPWCSSD-HSZRJFAPSA-N
- XLogP
- 3.1
- Polar surface area
- 49.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Parkinson disease
via ChEMBL · EBI
Research
173 papers- PET Imaging of brain muscarinic receptors with (18)F-Fluorobenzyl-Dexetimide: A first in human study.Psychiatry research. Neuroimaging · 2021
- Human biodistribution and internal dosimetry of 4-[ (18)F]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart.EJNMMI research · 2020
- [Effect of dexetimide on intra-ocular pressure].Revista do Hospital das Clinicas · 1975
- Comparison of atropine and dexetimide in treatment of intoxications by selected organophosphates.Acta pharmacologica et toxicologica · 1982
- Dexetimide, a useful tool in acetylcholine-receptor localization.European journal of pharmacology · 1973
via PubMed
Wikidata facts
- Mass
- 362.199428
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₃H₂₆N₂O₂
- subject has role
- parasympatholytic
- isomeric SMILES
- C1CN(CCC1[C@@]2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4
- canonical SMILES
- C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4
- defined daily dose
- 0.125
Sources (3)
via Wikidata · CC0
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via Wikidata sitelinks · CC0