Structure via PubChem · Public domain (PubChem)
دکسرازوکسان
Sign in to saveAlso known as DRX187, ADR-529, ICRF-187, (+)-1,2-bis(3,5-dioxo-1-piperazinyl)propane, (+)-(S)-4,4′-propylenedi-2,6-piperazinedione, dextrorazoxane
Dexrazoxane hydrochloride, sold under the brand name Zinecard among others, is a cardioprotective agent. It was discovered in 1972. The IV administration of dexrazoxane is in acidic condition with HCl adjusting the pH.
Chemical data
- Formula
- C11H16N4O4
- Molecular weight
- 268.27 g/mol
- IUPAC name
- 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
- SMILES
- C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
- InChIKey
- BMKDZUISNHGIBY-ZETCQYMHSA-N
- XLogP
- -1.4
- Polar surface area
- 98.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1995
- Admin. routes
- parenteral
- Indications
- Ewing sarcoma, myelodysplastic syndrome, acute lymphoblastic leukemia, acute myeloid leukemia
via ChEMBL · EBI
Research
810 papers- Dexrazoxane.2006
- Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines.The Cochrane database of systematic reviews · 2022
- Dexrazoxane.2026
- Dexrazoxane and Long-Term Heart Function in Survivors of Childhood Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
- Efficacy of Dexrazoxane in Cardiac Protection in Pediatric Patients Treated With Anthracyclines.Cureus · 2023
via PubMed
Wikidata facts
- Mass
- 268.117155
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₁H₁₆N₄O₄
- medical condition treated
- breast cancer
- canonical SMILES
- CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
- isomeric SMILES
- C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
- World Health Organisation international non-proprietary name
- dexrazoxane
- defined daily dose
- 1.5
- Commons category
- Dexrazoxane
via Wikidata · CC0