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dichloroisoprenaline
Sign in to saveAlso known as DCI, Dichloroisoproterenol
Dichloroisoprenaline (DCI), also known as dichloroisoproterenol, was the first beta blocker ever to be developed. It is non-selective for the β1-adrenergic and β2-adrenergic receptors. DCI has low potency and acts as a partial agonist/antagonist at these receptors.
Chemical data
- Formula
- C11H15Cl2NO
- Molecular weight
- 248.15 g/mol
- IUPAC name
- 1-(3,4-dichlorophenyl)-2-(propan-2-ylamino)ethanol
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 247.053
Show 3 more facts
- chemical formula
- C₁₁H₁₅Cl₂NO
- canonical SMILES
- CC(C)NCC(C1=CC(=C(C=C1)Cl)Cl)O
- Commons category
- Dichloroisoprenaline
Sources (2)
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Encyclopedic overview
1 sectionsContents
- References
Dichloroisoprenaline (DCI), also known as dichloroisoproterenol, was the first beta blocker ever to be developed. It is non-selective for the β1-adrenergic and β2-adrenergic receptors. DCI has low potency and acts as a partial agonist/antagonist at these receptors.
Although DCI was of no clinical value itself, further developments from DCI eventually led to the development of the clinical candidate pronethalol (withdrawn due to carcinogenicity) and subsequently propranolol (the first clinically successful beta blocker).
Excerpted from Wikipedia’s “dichloroisoprenaline” article, available under the CC BY-SA 4.0 licence.
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