Structure via PubChem · Public domain (PubChem)
ipratropium bromide
Sign in to saveAlso known as (Endo,syn)-(+-)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide, 3alpha-Hydroxy-8-isopropyl-1alphah,5alphah-tropanium bromide (+-)-tropate, ipratropium bromide anhydrous, ipratropii bromidum, ipratropium bromide (anhydrous), 8-isopropylnoratropine methobromide, N-isopropylnoratropinium bromomethylate
chemical compound
Key facts
- Trade names
- Atrovent, others
- Ahfs drugs com
- Monograph
- Medlineplus
- a618013
- License data
- United States</span>"}]]}'>US DailyMed : Ipratropium bromide
- Pregnancy category
- Australia</span>"}]]}'>AU : B1
- Routes of administration
- Inhalation , intranasal
- Drug class
- Anticholinergic ( muscarinic antagonist )
- Atc code
- R01AX03 ( WHO ) R03BB01 ( WHO )
- Legal status
- New Zealand</span>"}]]}'>NZ : Prescription only United Kingdom</span>"}]]}'>UK : POM (Prescription only) United States</span>"}]]}'>US : ℞-only
- Protein binding
- 0–9% in vitro
- Metabolism
- Liver
- Onset of action
- 15–30 minutes
- Elimination half life
- 2 hours
- Duration of action
- 3–5 hours
- Cas number
- 22254-24-6 Ipratropium: 60205-81-4
- Drugbank
- DBSALT002739 Ipratropium: DB00332
- Unii
- J697UZ2A9J Ipratropium: GR88G0I6UL
- Kegg
- D02212
via Wikipedia infobox
Chemical data
- Formula
- C20H30BrNO3
- Molecular weight
- 412.4 g/mol
- IUPAC name
- [(1S,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide
- SMILES
- CC(C)[N+]1([C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.[Br-]
- InChIKey
- LHLMOSXCXGLMMN-CLTUNHJMSA-M
- Polar surface area
- 46.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 411.14090591999997
Show 5 more facts
- isomeric SMILES
- [Br-].CC(C)[N+]1(C)[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)C(CO)c3ccccc3
- chemical formula
- C₂₀H₃₀BrNO₃
- Commons category
- Ipratropium bromide
- defined daily dose
- 0.24
- canonical SMILES
- CC(C)[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2.[Br-]
Sources (3)
via Wikidata · CC0
~9 min read
Article
Ipratropium bromide, sold under the trade name Atrovent among others, is a type of anticholinergic medication which is applied by different routes: inhaler, nebulizer, or nasal spray, for different reasons.
The inhalant opens up the medium and large airways in the lungs. It is used to treat the symptoms of chronic obstructive pulmonary disease (COPD) and asthma. It is used by inhaler or nebulizer. Onset of action is typically within 15 to 30 minutes and lasts for three to five hours.