Structure via PubChem · Public domain (PubChem)
DIDS
Sign in to saveAlso known as 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, ABC inhibitor 2, 2,2'-ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonic acid), 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid, 4,4'-diisothiocyanato-2,2'-stilbenedisulfonic acid
4,4′-Diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor, blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.
Chemical data
- Formula
- C16H10N2O6S4
- Molecular weight
- 454.5 g/mol
- IUPAC name
- 5-isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid
- SMILES
- C1=CC(=C(C=C1N=C=S)S(=O)(=O)O)C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)O
- InChIKey
- YSCNMFDFYJUPEF-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 214 Ų
- H-bond donors
- 2
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Research
4,170 papers- DIDS inhibits Vibrio vulnificus cytotoxicity by interfering with TolC-mediated RtxA1 toxin secretion.European journal of pharmacology · 2020
- Molecular Determinant of DIDS Analogs Targeting RAD51 Activity.Molecules (Basel, Switzerland) · 2021
- DIDS inhibits overexpression BAK1-induced mitochondrial apoptosis through GSK3β/β-catenin signaling pathway.Journal of cellular physiology · 2018
- DIDS reduces ischemia/reperfusion-induced myocardial injury in rats.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2015
- Synthesis and biological evaluation of DIDS analogues as efficient inhibitors of RAD51 involved in homologous recombination.Bioorganic & medicinal chemistry letters · 2023
via PubMed
Wikidata facts
- Subclass of
- stilbenoid
- Mass
- 453.94217
Show 2 more facts
- chemical formula
- C₁₆H₁₀N₂O₆S₄
- canonical SMILES
- C1=CC(=C(C=C1N=C=S)S(=O)(=O)O)C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)O
Sources (3)
via Wikidata · CC0
Article · 日本語
4,4'-ジイソチオシアノ-2,2'-スチルベンジスルホン酸（4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, DIDS）は、その構造から明らかなようにイソチオシアネートに分類される化合物の1種である。通常、DIDSと略す。
Abstract from DBpedia / Wikipedia · CC BY-SA