diflunisal
Sign in to saveAlso known as 5-(2,4-difluorophenyl)salicylic acid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid, 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971, after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, by Merck & Co., but generic versions are widely available. It is classed as a nonsteroidal anti-inflammatory drug (NSAID) and is available in 250 mg and 500 mg tablets.
Key facts
- Drug.verifiedrevid
- 460785966
- Drug.image
- Diflunisal structure.svg
- Drug.width
- 180
- Drug.image_class
- skin-invert-image
- Drug.image2
- Diflunasil-3D-balls.png
- Drug.width2
- 187
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Dolobid
- Drug.MedlinePlus
- a684037
- Drug.DailyMedID
- Diflunisal
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N02
- Drug.ATC_suffix
- BA11
- Drug.legal_AU
- S4
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
via Wikipedia infobox
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 250.044
- Has use
- medication
Show 8 more facts
- World Health Organisation international non-proprietary name
- diflunisal
- chemical formula
- C₁₃H₈F₂O₃
- medical condition treated
- rheumatoid arthritis
- canonical SMILES
- C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O
- defined daily dose
- 0.75
- Commons category
- Diflunisal
- physically interacts with
- Prostaglandin-endoperoxide synthase 1
- legal status (medicine)
- boxed warning
Sources (8)
via Wikidata · CC0
~3 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Contraindications
- Amyloidosis
- Side effects
- Mechanism of action
- Duration of effect
- Society and culture
- Legal status
- Research
- References
- Further reading
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971, after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, by Merck & Co., but generic versions are widely available. It is classed as a nonsteroidal anti-inflammatory drug (NSAID) and is available in 250 mg and 500 mg tablets.
==Medical uses== Diflunisal is indicated for acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis.
Excerpted from Wikipedia’s “diflunisal” article, available under the CC BY-SA 4.0 licence.