File:Digoxin.svg · Wikimedia Commons · See Wikimedia Commons
ديجوكسين
Sign in to saveAlso known as Lanoxicaps, Lanoxin, Vanoxin, Lanoxin Pediatric, Digoxin Pediatric, 12beta-Hydroxydigitoxin, Digossina, Lanadicor
مركب كيميائي
OverviewAI-generated
Digoxin is a chemical compound with the formula C₄₁H₆₄O₁₄. It has a mass of 780.43 and a defined daily dose of 0.25. The substance is characterized by a charge of 0, an xlogp of 1.3, and a tpsa of 203. Its structure includes 6 hydrogen bond donors and 14 hydrogen bond acceptors.
The compound is associated with a weight of 780.9. It has been the subject of 17680 entries in PubMed literature. Additionally, digoxin is referenced by 341 other encyclopedia articles.
Synthesized by Vinony from 16 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Chemical data
- Formula
- C41H64O14
- Molecular weight
- 780.9 g/mol
- IUPAC name
- 3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
- SMILES
- C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
- InChIKey
- LTMHDMANZUZIPE-PUGKRICDSA-N
- XLogP
- 1.3
- Polar surface area
- 203 Ų
- H-bond donors
- 6
- H-bond acceptors
- 14
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1975
- Admin. routes
- oral, parenteral
- Indications
- epilepsy, hepatitis C virus infection, atrial fibrillation, cardiovascular disease
via ChEMBL · EBI
Research
17,680 papers- Expert Consensus on the Diagnosis and Management of Digoxin Toxicity.The American journal of medicine · 2025
- Role of Digoxin in Atrial Fibrillation.Journal of pharmacy practice · 2017
- Digoxin and nifedipine.The American journal of cardiology · 1985
- [Digoxin].Nihon rinsho. Japanese journal of clinical medicine · 2004
- [Digoxin].Nederlands tijdschrift voor geneeskunde · 1988
via PubMed
Wikidata facts
- Mass
- 780.43
- Has use
- medication
Show 11 more facts
- chemical formula
- C₄₁H₆₄O₁₄
- Commons category
- Digoxin
- medical condition treated
- supraventricular tachycardia
- isomeric SMILES
- C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
- canonical SMILES
- CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
- World Health Organisation international non-proprietary name
- digoxin
- subject has role
- essential medicine
- found in taxon
- Digitalis viridiflora
- defined daily dose
- 0.25
- significant drug interaction
- furosemide
- associated hazard
- digoxin toxicity
via Wikidata · CC0
Article · العربية
الديجوكسين (بالإنجليزية: Digoxin) أو ديجيتالس هو دواء يستخدم لعدد من الأمراض القلبية يتم استخراجه من النبتة الديجيتال الصوفي. يقوم الديجوكسين بزيادة انقباضية عضلة القلب وتقليل قابلية العقدة الأذينية البطينية (AV node) لتوصيل النبضات العصبية، ويتم ذلك عن طريق تثبيط عمل مضخة الصوديوم والبوتاسيوم مما يعمل على زيادة تركيز الكالسيوم داخل الخلية العضلية. ويستخدم في علاج: 1. * الحالات المختلفة من اللانظميات فوق البطينية وبخاصة الرجفان الأذيني. 2. * قصور القلب حيث يقوم الدواء بزيادة قدرة القلب على ضخ الدم.
Abstract from DBpedia / Wikipedia · CC BY-SA