Digoxina

Also known as Lanoxicaps, Lanoxin, Vanoxin, Lanoxin Pediatric, Digoxin Pediatric, 12beta-Hydroxydigitoxin, Digossina, Lanadicor

compuesto químico

OverviewAI-generated

Digoxin is a chemical compound with the formula C₄₁H₆₄O₁₄. It has a mass of 780.43 and a defined daily dose of 0.25. The substance is characterized by a charge of 0, an xlogp of 1.3, and a tpsa of 203. Its structure includes 6 hydrogen bond donors and 14 hydrogen bond acceptors.

The compound is associated with a weight of 780.9. It has been the subject of 17680 entries in PubMed literature. Additionally, digoxin is referenced by 341 other encyclopedia articles.

Synthesized by Vinony from 16 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

In the Vinony graph

Vinony's link graph records 341 inbound references to Digoxina, and connects out to heart arrhythmia, electrocardiography and intravenous infusion and defusion.

It sits within the topics Cardenolides, Drugboxes which contain changes to watched fields and ECHA InfoCard ID from Wikidata.

Vinony links it to 42 Wikipedia language editions.

Chemical data

Formula: C41H64O14
Molecular weight: 780.9 g/mol
IUPAC name: 3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
InChIKey: LTMHDMANZUZIPE-PUGKRICDSA-N
XLogP: 1.3
Polar surface area: 203 Å²
H-bond donors: 6
H-bond acceptors: 14
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1975
Admin. routes: oral, parenteral
Indications: epilepsy, hepatitis C virus infection, atrial fibrillation, cardiovascular disease

via ChEMBL · EBI

Research

17,680 papers

Expert Consensus on the Diagnosis and Management of Digoxin Toxicity.The American journal of medicine · 2025
Role of Digoxin in Atrial Fibrillation.Journal of pharmacy practice · 2017
Digoxin and nifedipine.The American journal of cardiology · 1985
[Digoxin].Nihon rinsho. Japanese journal of clinical medicine · 2004
[Digoxin].Nederlands tijdschrift voor geneeskunde · 1988

via PubMed

Wikidata facts

Mass: 780.43
Has use: medication

Show 11 more facts

chemical formula: C₄₁H₆₄O₁₄
Commons category: Digoxin
medical condition treated: supraventricular tachycardia
isomeric SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
canonical SMILES: CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
World Health Organisation international non-proprietary name: digoxin
subject has role: essential medicine
found in taxon: Digitalis viridiflora
defined daily dose: 0.25
significant drug interaction: furosemide
associated hazard: digoxin toxicity

Sources (5)

via Wikidata · CC0

Article · Español

La digoxina es un glucósido cardiotónico, usado como agente antiarrítmico empleado en la insuficiencia cardíaca, y utilizado en otros trastornos cardíacos como la fibrilación auricular. Actúa, como efecto directo, inhibiendo la bomba Na+ K+ ATPasa en el corazón, disminuyendo la salida de Na+ y aumentando los niveles de Ca+2 intracelular, por lo que tiene un efecto inotrópico positivo, aumentando la fuerza de contracción del músculo cardíaco; y como efecto indirecto inhibe la bomba Na+ K+ ATPasa a nivel neural, creando una estimulación vagal que disminuye la frecuencia cardíaca y la estimulación simpática. Es un extracto de la planta espermatofita Digitalis lanata y su aglicona correspondiente, es decir, la porción no glucosilada es la digoxigenina. La digoxina está disponible en comprimidos, en solución inyectable y en gotas bebibles.

Abstract from DBpedia / Wikipedia · CC BY-SA