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GeneQ17914024· pop 7· linked from 31 articles

DMRT1

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Also known as CT154, DMT1, doublesex and mab-3 related transcription factor 1

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.

Gene data

DMRT1

Name: doublesex and mab-3 related transcription factor 1
Type: protein-coding
Position: 841,690–969,090 (+)
Aliases: CT154, DMT1
Ensembl: ENSG00000137090
RefSeq RNA: NM_001363767.1, NM_021951.3, XM_006716732.2, XM_011517770.2, XM_011517771.2
RefSeq protein: NP_001350696.1, NP_068770.2, XP_006716795.1, XP_011516072.2, XP_011516073.2

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II male germ cell proliferation male germ cell proliferation regulation of DNA-templated transcription regulation of transcription by RNA polymerase II sex differentiation male sex determination

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding

Cellular component

chromatin nucleus nucleus nucleus nucleus cytoplasm

Pathways

Developmental Biology Transcriptional regulation of testis differentiation Somatic sex determination Mammalian disorder of sexual development

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 9280
genomic start: 841690
exact match: identifiers.org/ncbigene/1761
genomic end: 969090
cytogenetic location: 9p24.3

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Article

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Contents

Function
References
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External links

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.

== Function ==

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Categories

Genes on human chromosome 9 Transcription factors