DYNLT1

Also known as CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.

In the Vinony graph

Within Vinony's link graph, DYNLT1 is referenced by 272 other articles, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 6.

Its subject is documented across 6 Wikipedia language editions.

Gene data

DYNLT1

Name: dynein light chain Tctex-type 1
Type: protein-coding
Position: 158,612,721–158,644,771 (−)
Aliases: CW-1, TCTEL1, TCTEX1, tctex-1
Ensembl: ENSG00000146425
RefSeq RNA: NM_001291602.2, NM_001291603.2, NM_006519.4
RefSeq protein: NP_001278531.1, NP_001278532.1, NP_006510.1

This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].

Gene Ontology

Biological process

establishment of mitotic spindle orientation microtubule-based movement regulation of G protein-coupled receptor signaling pathway intracellular transport of viral protein in host cell positive regulation of intracellular transport intraciliary retrograde transport negative regulation of neurogenesis positive regulation of mitotic cell cycle spindle assembly checkpoint

Molecular function

protein binding identical protein binding dynein intermediate chain binding

Cellular component

male germ cell nucleus extracellular region cytoplasm cytoplasm Golgi apparatus spindle cytosol cytoplasmic dynein complex

Pathways

Salmonella infection - Homo sapiens (human)Disease Innate Immune System Immune System Infectious disease Neutrophil degranulation Viral Infection Pathways Dengue Virus Infection Dengue Virus-Host Interactions Ciliary landscape

via MyGene.info

Gene · Ensembl

dynein light chain Tctex-type 1

Symbol: DYNLT1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:158,612,721-158,644,771
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 4754
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6993
genomic start: 159057506
genomic end: 158644743
chromosome: human chromosome 6
cytogenetic location: 6q25.3

Sources (4)

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Encyclopedic overview

2 sections

Contents

References
Further reading

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]

Excerpted from Wikipedia’s “DYNLT1” article, available under the CC BY-SA 4.0 licence.