Dolasetron

Arzneistoff

Chemical data

Formula: C19H20N2O3
Molecular weight: 324.4 g/mol
IUPAC name: [(7R)-10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl] 1H-indole-3-carboxylate
SMILES: C1[C@@H]2CC(CC3N2CC(=O)C1C3)OC(=O)C4=CNC5=CC=CC=C54
InChIKey: UKTAZPQNNNJVKR-DBBXXEFVSA-N
XLogP: 3.4
Polar surface area: 62.4 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1997
Admin. routes: oral, parenteral
Indications: fibromyalgia, Chemotherapy-induced nausea and vomiting, Nausea

via ChEMBL · EBI

Research

313 papers

Dolasetron.2006
Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery.Drugs · 1997
Dolasetron overdose resulting in prolonged QTc interval and severe hypotension: a case report and literature review.Emergency medicine journal : EMJ · 2007
Dolasetron: a new option for nausea and vomiting.Journal of the American Animal Hospital Association · 2000
Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.The Cochrane database of systematic reviews · 2020

via PubMed

Wikidata facts

Has part: hydrogen
Mass: 324.1473925
Has use: medication

Show 7 more facts

canonical SMILES: O=C(OC1CC2CC3CC(C1)N2CC3=O)c1c[nH]c2ccccc12
chemical formula: C₁₉H₂₀N₂O₃
medical condition treated: vomiting
World Health Organisation international non-proprietary name: dolasetron
isomeric SMILES: O=C(O[C@@H]1C[C@@H]2C[C@H]3C[C@H](C1)N2CC3=O)c4c[nH]c5ccccc45
NCI Thesaurus ID: C61735
subject has role: antiemetic

Sources (2)

via Wikidata · CC0

Article · Deutsch

Dolasetron ist ein 5-HT3-Antagonist zur Behandlung von Übelkeit und Erbrechen in der Chemotherapie und bei PONV. Dolasetron wird in einer Dosierung von 50 bis 200 Milligramm verabreicht. Die Halbwertszeit beträgt 7 bis 9 Stunden. Der Abbau erfolgt über das Enzym Cytochrom P450 2D6. Auch in der Tiermedizin wird es gegen Erbrechen angewendet.

Abstract from DBpedia / Wikipedia · CC BY-SA

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