dolasetron

Chemical data

Formula

C19H20N2O3

Molecular weight

324.4 g/mol

IUPAC name

[(7R)-10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl] 1H-indole-3-carboxylate

SMILES

C1[C@@H]2CC(CC3N2CC(=O)C1C3)OC(=O)C4=CNC5=CC=CC=C54

InChIKey

UKTAZPQNNNJVKR-DBBXXEFVSA-N

XLogP

3.4

Polar surface area

62.4 Ų

H-bond donors

1

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1997

Admin. routes

oral, parenteral

Indications

fibromyalgia, Chemotherapy-induced nausea and vomiting, Nausea

via ChEMBL · EBI

• Dolasetron.2006
• Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery.Drugs · 1997
• Dolasetron overdose resulting in prolonged QTc interval and severe hypotension: a case report and literature review.Emergency medicine journal : EMJ · 2007
• Dolasetron: a new option for nausea and vomiting.Journal of the American Animal Hospital Association · 2000
• Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.The Cochrane database of systematic reviews · 2020

via PubMed

Wikidata facts

Has part

hydrogen

Mass

324.1473925

Has use

medication

via Wikidata · CC0