Structure via PubChem · Public domain (PubChem)
دروندارون
Sign in to saveAlso known as SR-33598B, SR 33589B, SR 33589, SR 33589b, N-(2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-5-benzofuranyl)-methanesulfonamide, N-(2-butyl-3-{p-[3-(dibutylamino)propoxy]benzoyl}-5-benzofuranyl)methanesulfonamide
Dronedarone, sold under the brand name Multaq, is a class III antiarrhythmic medication developed by Sanofi-Aventis. It was approved by the US Food and Drug Administration (FDA) in July 2009. Besides being indicated in arrhythmias, it was recommended as an alternative to amiodarone for the treatment of atrial fibrillation and atrial flutter in people whose hearts have either returned to normal rhythm or who undergo drug therapy or electric shock treatment i.e. direct current cardioversion (DCCV) to maintain normal rhythm. It is a class III antiarrhythmic drug. The FDA label includes a claim fo
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 461091509
- Drug.image
- Dronedarone structure.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Multaq
- Drug.MedlinePlus
- a609034
- Drug.DailyMedID
- Dronedarone
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C01
- Drug.ATC_suffix
- BD07
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- 15% (with a high-fat meal)
via Wikipedia infobox
Chemical data
- Formula
- C31H44N2O5S
- Molecular weight
- 556.8 g/mol
- IUPAC name
- N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide
- SMILES
- CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC
- InChIKey
- ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
- XLogP
- 7.2
- Polar surface area
- 97.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2009
- Admin. routes
- oral
- Indications
- cardiac arrhythmia, atrial fibrillation, congestive heart failure, atrial flutter
via ChEMBL · EBI
Research
823 papers- Dronedarone.Drugs of today (Barcelona, Spain : 1998) · 2011
- Dronedarone.Circulation · 2009
- Dronedarone a comprehensive drug profile.Profiles of drug substances, excipients, and related methodology · 2025
- Dronedarone.Drugs · 2009
- Dronedarone vs Sotalol Among Patients With Atrial Fibrillation: A Meta-Analysis of Retrospective Observational Databases.JACC. Clinical electrophysiology · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 556.297094
- Has use
- medication
Show 8 more facts
- medical condition treated
- atrial fibrillation
- significant drug interaction
- ketoconazole
- chemical formula
- C₃₁H₄₄N₂O₅S
- canonical SMILES
- CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC
- World Health Organisation international non-proprietary name
- dronedarone
- defined daily dose
- 0.8
- Commons category
- Dronedarone
- legal status (medicine)
- boxed warning
Sources (6)
via Wikidata · CC0