DUSP1

Also known as CL100, HVH1, MKP-1, MKP1, PTPN10, dual specificity phosphatase 1

gen de la especie Homo sapiens

In the Vinony graph

Within Vinony's link graph, DUSP1 is referenced by 88 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.

It sits within the topics EC 3.1.3 and Genes on human chromosome 5.

Its subject is documented across 4 Wikipedia language editions.

Gene data

DUSP1

Name: dual specificity phosphatase 1
Type: protein-coding
Position: 172,766,992–172,771,198 (−)
Aliases: CL100, HVH1, MKP-1, MKP1, PTPN10
Ensembl: ENSG00000120129
RefSeq RNA: NM_004417.4
RefSeq protein: NP_004408.1

The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017].

Pathways

MAPK signaling pathway - Homo sapiens (human)Serotonergic synapse - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Fluid shear stress and atherosclerosis - Homo sapiens (human)RAF-independent MAPK1/3 activation Signal Transduction RAF/MAP kinase cascade Negative regulation of MAPK pathway MAPK family signaling cascades MAPK1/MAPK3 signaling

via MyGene.info

Gene · Ensembl

dual specificity phosphatase 1

Symbol: DUSP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:172,766,992-172,771,198
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 3254
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1843
genomic end: 172198198
genomic start: 172768096
chromosome: human chromosome 5
cytogenetic location: 5q35.1
expressed in: trachea

Sources (4)

via Wikidata · CC0

Article · Español

La proteína fosfatasa dual específica 1 (DUSP1) es una enzima codificada en humanos por el gen dusp1. La expresión del gen dusp1 es inducida en fibroblastos de piel humanos por estrés oxidativo/térmico y por factores de crecimiento. La proteína que codifica, DUSP1, presenta unas características estructurales similares a los miembros de la familia de proteínas tirosina fosfatasas no receptoras, y tiene una significativa similitud de secuencia de aminoácidos con tirosina/serina fosfatasa codificada por el último gen H1 del virus vaccinia. La proteína DUSP1 expresada y purificada desde bacterias mantiene su actividad fosfatasa intrtínseca, e inactiva específicamente a MAP quinasas in vitro por la defosforilación concomitante tanto de su residuo de fosfotreonina como de su residuo de fosfotirosina. Además, suprime la activación de las MAP quinasas por la proteína Ras en extractos de . Por ello, DUSP1 podría jugar un importante papel en la respuesta celular a estrés ambiental, así como en la regulación negativa de la proliferación celular.

Abstract from DBpedia / Wikipedia · CC BY-SA