DUSP7

Also known as MKPX, PYST2, dual specificity phosphatase 7

Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.

In the Vinony graph

Within Vinony's link graph, DUSP7 is referenced by 83 other articles, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.

Vinony files it under EC 3.1.3 and Genes on human chromosome 3.

Its subject is documented across 4 Wikipedia language editions.

Gene data

DUSP7

Name: dual specificity phosphatase 7
Type: protein-coding
Aliases: MKPX, PYST2

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009].

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