Also known as THR790MET, RS121434569
T790M, also known as Thr790Met, is a gatekeeper mutation of the epidermal growth factor receptor (EGFR). The mutation substitutes a threonine (T) with a methionine (M) at position 790 of exon 20, affecting the ATP binding pocket of the EGFR kinase domain. Threonine is a small polar amino acid; methionine is a larger nonpolar amino acid. Rather than directly blocking inhibitor binding to the active site, T790M increases the affinity for ATP so that the inhibitors are outcompeted; irreversible covalent inhibitors such as osimertinib can overcome this resistance.
T790M, aussi connu comme Thr790Met, est une mutation du facteur de croissance épidermique (EGFR). La mutation substitue une thréonine (T) avec une méthionine (M) à la position 790 de l'exon 20, affectant la poche de liaison à l'ATP du domaine EGFR kinase. La thréonine est un petit acide aminé polaire; la méthionine est un acide aminé non polaire plus grand.
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).