エプレレノン

Chemical data

Formula

C24H30O6

Molecular weight

414.5 g/mol

IUPAC name

methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate

SMILES

C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC

InChIKey

JUKPWJGBANNWMW-VWBFHTRKSA-N

XLogP

1.4

Polar surface area

82.2 Ų

H-bond donors

0

H-bond acceptors

6

Formal charge

0

via PubChem

• Eplerenone.Nature reviews. Drug discovery · 2003
• Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial.Journal of the American Society of Nephrology : JASN · 2022
• Comparative effectiveness and safety of eplerenone and spironolactone in patients with heart failure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2024
• Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.The New England journal of medicine · 2003
• When to use spironolactone, eplerenone or finerenone in the spectrum of cardiorenal diseases.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024

via PubMed

Wikidata facts

Mass

414.204239

via Wikidata · CC0