Structure via PubChem · Public domain (PubChem)
cipralisant
Sign in to saveAlso known as (1S,2S)-4-(2-(5,5-dimethylhex-1-inyl)-cyclopropyl)imidazol, gt-2342, GT-2342, (+)-cipralisant
Cipralisant (GT-2331, tentative trade name Perceptin) is an extremely potent histamine H3 receptor ligand originally developed by Gliatech. Cipralisant was initially classified as a selective H3 antagonist, but newer research (2005) suggests also agonist properties, i.e., functional selectivity.
Chemical data
- Formula
- C14H20N2
- Molecular weight
- 216.32 g/mol
- IUPAC name
- 5-[(1S,2S)-2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole
- SMILES
- CC(C)(C)CCC#C[C@H]1C[C@@H]1C2=CN=CN2
- InChIKey
- CVKJAXCQPFOAIN-RYUDHWBXSA-N
- XLogP
- 3.3
- Polar surface area
- 28.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 216.163
Show 4 more facts
- canonical SMILES
- CC(C)(C)CCC#CC1CC1C2=CN=CN2
- chemical formula
- C₁₄H₂₀N₂
- isomeric SMILES
- CC(C)(C)CCC#C[C@H]1C[C@@H]1C2=CN=CN2
- Commons category
- Cipralisant
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Cipralisant (GT-2331, tentative trade name Perceptin) is an extremely potent histamine H3 receptor ligand originally developed by Gliatech. Cipralisant was initially classified as a selective H3 antagonist, but newer research (2005) suggests also agonist properties, i.e., functional selectivity.
The relatively recent cloning of human H3 receptor, as well as the discovery of its constitutive activity provided the ability to better assess the activity of H3 receptor ligands. Consequently, cipralisant was reassessed as an H3 receptor agonist in human and rat recombinant systems, showing functional selectivity and stimulating one type of G-protein coupled pathway while failing to activate other intracellular pathways.
Excerpted from Wikipedia’s “cipralisant” article, available under the CC BY-SA 4.0 licence.