zofenopril

Also known as SO-26991, SQ-26900, Zofenoprilum, Zofénopril, Zofenil

Zofenopril (INN) is a medication that protects the heart and helps reduce high blood pressure. It is an angiotensin-converting enzyme (ACE) inhibitor.

In the Vinony graph

Vinony's link graph records 80 inbound references to zofenopril, and connects out to angiotensins, amlodipine/valsartan and perindopril.

Vinony files it under ACE inhibitors, Carboxamides and Drugboxes which contain changes to verified fields.

Vinony links it to 16 Wikipedia language editions.

Chemical data

Formula: C22H23NO4S2
Molecular weight: 429.6 g/mol
IUPAC name: (2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
SMILES: C[C@H](CSC(=O)C1=CC=CC=C1)C(=O)N2C[C@H](C[C@H]2C(=O)O)SC3=CC=CC=C3
InChIKey: IAIDUHCBNLFXEF-MNEFBYGVSA-N
XLogP: 4.4
Polar surface area: 125 Å²
H-bond donors: 1
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: cardiovascular disease

via ChEMBL · EBI

Research

215 papers

Efficacy of Zofenopril Alone or in Combination with Hydrochlorothiazide in Patients with Kidney Dysfunction.Current clinical pharmacology · 2019
Zofenopril: Blood pressure control and cardio-protection.Cardiology journal · 2022
Zofenopril plus hydrochlorothiazide: Combination therapy for the treatment of mild to moderate hypertension.Drugs · 2006
Angiotensin-Converting Enzyme Inhibition: Beyond Blood Pressure Control-The Role of Zofenopril.Advances in therapy · 2020
Long-term clinical experience with zofenopril.Expert review of cardiovascular therapy · 2012

via PubMed

Wikidata facts

Mass: 429.10685
Has use: medication

Show 9 more facts

subject has role: antihypertensive drug
chemical formula: C₂₂H₂₃NO₄S₂
canonical SMILES: CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)O)SC3=CC=CC=C3
isomeric SMILES: C[C@H](CSC(=O)C1=CC=CC=C1)C(=O)N2C[C@H](C[C@H]2C(=O)O)SC3=CC=CC=C3
World Health Organisation international non-proprietary name: zofenopril
medical condition treated: arterial hypertension
physically interacts with: angiotensin I converting enzyme
Commons category: Zofenopril
defined daily dose: 30

Sources (5)

via Wikidata · CC0

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Encyclopedic overview

1 sections

Contents

References

Zofenopril (INN) is a medication that protects the heart and helps reduce high blood pressure. It is an angiotensin-converting enzyme (ACE) inhibitor.

In small studies, zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs, atenolol and enalapril, and was associated with fewer adverse effects.

Excerpted from Wikipedia’s “zofenopril” article, available under the CC BY-SA 4.0 licence.