Structure via PubChem · Public domain (PubChem)
ertugliflozin
Sign in to saveAlso known as MK-8835, PF-04971729, ertugliflozine
Ertugliflozin, sold under the brand name Steglatro, is a medication used for the treatment of type 2 diabetes.
Key facts
- Drug.image
- Ertugliflozin.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Steglatro
- Drug.DailyMedID
- Ertugliflozin
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Antidiabetic agent
- Drug.ATC_prefix
- A10
- Drug.ATC_suffix
- BK04
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- ~100%
- Drug.protein_bound
- 93.6%
- Drug.metabolism
- UGT1A9, UGT2B7
- Drug.metabolites
- Glucuronides
- Drug.elimination_half life
- ~17 hours
via Wikipedia infobox
Chemical data
- Formula
- C22H25ClO7
- Molecular weight
- 436.9 g/mol
- IUPAC name
- (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
- SMILES
- CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@@]34[C@@H]([C@H]([C@@H]([C@@](O3)(CO4)CO)O)O)O)Cl
- InChIKey
- MCIACXAZCBVDEE-CUUWFGFTSA-N
- XLogP
- 1.7
- Polar surface area
- 109 Ų
- H-bond donors
- 4
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Admin. routes
- oral
- Indications
- diabetes mellitus, heart failure, type 2 diabetes mellitus, Mitral regurgitation
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 436.128881
Show 7 more facts
- canonical SMILES
- CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)Cl
- chemical formula
- C₂₂H₂₅ClO₇
- isomeric SMILES
- CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@@]34[C@@H]([C@H]([C@@H]([C@@](O3)(CO4)CO)O)O)O)Cl
- medical condition treated
- type 2 diabetes
- Commons category
- Ertugliflozin
- defined daily dose
- 10
- subject has role
- gliflozins
Sources (6)
via Wikidata · CC0
~4 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Society and culture
- Legal status
- References
Ertugliflozin, sold under the brand name Steglatro, is a medication used for the treatment of type 2 diabetes.
The most common side effects include fungal infections of the vagina and other infections of the female reproductive system.
Excerpted from Wikipedia’s “ertugliflozin” article, available under the CC BY-SA 4.0 licence.