Structure via PubChem · Public domain (PubChem)
fantofarone
Sign in to saveFantofarone is a calcium channel blocker.
Chemical data
- Formula
- C31H38N2O5S
- Molecular weight
- 550.7 g/mol
- IUPAC name
- N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-3-[4-(2-propan-2-ylindolizin-1-yl)sulfonylphenoxy]propan-1-amine
- SMILES
- CC(C)C1=CN2C=CC=CC2=C1S(=O)(=O)C3=CC=C(C=C3)OCCCN(C)CCC4=CC(=C(C=C4)OC)OC
- InChIKey
- ITAMRBIZWGDOHW-UHFFFAOYSA-N
- XLogP
- 6.7
- Polar surface area
- 77.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
51 papers- Fantofarone (SR 33557): effect on post-ischaemic functional recovery in perfused rat hearts.European journal of pharmacology · 1992
- Fantofarone (SR 33557): cardiovascular actions in anesthetized dogs.Archives internationales de pharmacodynamie et de therapie · 1994
- Effects of two chemically related new Ca2+ channel antagonists, SR33557 (fantofarone) and SR33805, on the L-type cardiac channel.European journal of pharmacology · 1994
- Interaction of the calcium antagonist fantofarone with phospholipids: electrostatic effects.Biochemical pharmacology · 1994
- Fantofarone (SR33557): effects on myocardial oxygen consumption and coronary blood flow.Pharmacology · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 550.25
Show 3 more facts
- canonical SMILES
- CC(C)C1=CN2C=CC=CC2=C1S(=O)(=O)C3=CC=C(C=C3)OCCCN(C)CCC4=CC(=C(C=C4)OC)OC
- chemical formula
- C₃₁H₃₈N₂O₅S
- subject has role
- calcium channel blocker
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- Comparison with verapamil
- References
{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 346459924 | ImageFile=Fantofarone.svg | ImageSize= | PIN=N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-3-{4-[2-(propan-2-yl)indolizine-1-sulfonyl]phenoxy}propan-1-amine | OtherNames= |Section1= |Section2= |Section3= }}
Fantofarone is a calcium channel blocker.
Excerpted from Wikipedia’s “fantofarone” article, available under the CC BY-SA 4.0 licence.