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fenspiride
Sign in to saveFenspiride (INN, brand names Eurespal, Pneumorel and others) is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. The pharmacotherapeutic classification is antitussives. In Russia it was approved for the treatment of acute and chronic inflammatory diseases of ENT organs (ear, nose, throat) and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma. Russia, Romania, France and other European countries withdrew fenspiride-based drugs from the market due to th
Chemical data
- Formula
- C15H20N2O2
- Molecular weight
- 260.33 g/mol
- IUPAC name
- 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
- SMILES
- C1CN(CCC12CNC(=O)O2)CCC3=CC=CC=C3
- InChIKey
- FVNFBBAOMBJTST-UHFFFAOYSA-N
- XLogP
- 2.1
- Polar surface area
- 41.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- Airway obstruction
via ChEMBL · EBI
Research
79 papers- [The study of fenspiride: goals and objectives for chemical and toxicological studies].Sudebno-meditsinskaia ekspertiza · 2019
- Fenspiride: an anti-inflammatory drug with potential benefits in the treatment of endotoxemia.European journal of pharmacology · 1995
- Antitussive and antibronchoconstriction actions of fenspiride in guinea-pigs.The European respiratory journal · 1995
- [Fenspiride-a new alternative on the therapy of obstructive lung disease].Pneumologia (Bucharest, Romania) · 2003
- Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency - Role of physiological and other non-drug related parameters.Journal of clinical pharmacy and therapeutics · 2022
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 260.152478
- Has use
- medication
Show 5 more facts
- Commons category
- Fenspiride
- chemical formula
- C₁₅H₂₀N₂O₂
- World Health Organisation international non-proprietary name
- fenspiride
- canonical SMILES
- C1CN(CCC12CNC(=O)O2)CCC3=CC=CC=C3
- subject has role
- bronchodilator
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Fenspiride (INN, brand names Eurespal, Pneumorel and others) is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. The pharmacotherapeutic classification is antitussives. In Russia it was approved for the treatment of acute and chronic inflammatory diseases of ENT organs (ear, nose, throat) and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma. Russia, Romania, France and other European countries withdrew fenspiride-based drugs from the market due to the risk of QT prolongation and torsades de pointes. Fenspiride is known to have activity as an alpha-1 blocker, H1 antagonist, it also inhibits PDE3, PDE4, PDE5 with -logIC50 values of 3.44, 4.16, 3.8 respectively.
==References==
Excerpted from Wikipedia’s “fenspiride” article, available under the CC BY-SA 4.0 licence.
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