flunarizine
Sign in to saveAlso known as 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
Flunarizine, sold under the brand name Sibelium among others, is a drug classified as a calcium antagonist which is used for various indications. It is not available by prescription in the United States or Japan. The drug was discovered at Janssen Pharmaceutica (R14950) in 1968.
Research
2,026 papers- Flunarizine as prophylaxis for episodic migraine: a systematic review with meta-analysis.Pain · 2019
- Flunarizine in the treatment of vertigo.The Journal of laryngology and otology · 1983
- Flunarizine in migraine: a minireview.Headache · 1991
- Sublingual flunarizine.Headache · 1986
- Flunarizine. A reappraisal of its pharmacological properties and therapeutic use in neurological disorders.Drugs · 1989
via PubMed
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Encyclopedic overview
10 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- Research
- References
Flunarizine, sold under the brand name Sibelium among others, is a drug classified as a calcium antagonist which is used for various indications. It is not available by prescription in the United States or Japan. The drug was discovered at Janssen Pharmaceutica (R14950) in 1968.
==Medical uses== Flunarizine is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an add-on in the treatment of epilepsy where its effect is weak and not recommended. It has been shown to significantly reduce headache frequency and severity in both adults and children.
Excerpted from Wikipedia’s “flunarizine” article, available under the CC BY-SA 4.0 licence.