Structure via PubChem · Public domain (PubChem)
flutrimazole
Sign in to saveAlso known as 1-(2,4'-difluorotrityl)imidazole, 1-(o-Fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazole
Flutrimazole is a wide-spectrum antifungal drug. It is used for the topical treatment of superficial mycoses of the skin. Flutrimazole is an imidazole derivative. Its antifungal activity has been demonstrated in in vivo and in vitro studies to be comparable to that of clotrimazole and higher than bifonazole.
Chemical data
- Formula
- C22H16F2N2
- Molecular weight
- 346.4 g/mol
- IUPAC name
- 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
- SMILES
- C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=CC=C3F)N4C=CN=C4
- InChIKey
- QHMWCHQXCUNUAK-UHFFFAOYSA-N
- XLogP
- 4.6
- Polar surface area
- 17.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
32 papers- Toxicity studies with flutrimazole.Arzneimittel-Forschung · 1992
- Flutrimazole shampoo 1% versus ketoconazole shampoo 2% in the treatment of pityriasis versicolor. A randomised double-blind comparative trial.Mycoses · 2007
- Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1% cream. Efficacy of flutrimazole 1% dermal cream in dermatomycoses. Catalan Flutrimazole Study Group.Dermatology (Basel, Switzerland) · 1995
- Topical treatment of dermatophytosis and cutaneous candidosis with flutrimazole 1% cream: double-blind, randomized comparative trial with ketoconazole 2% cream.Mycoses · 1999
- A double-blind, randomized comparative trial: flutrimazole 1% solution versus bifonazole 1% solution once daily in dermatomycoses.Mycoses · 1995
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 346.128
Show 7 more facts
- chemical formula
- C₂₂H₁₆F₂N₂
- canonical SMILES
- C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=CC=C3F)N4C=CN=C4
- subject has role
- antifungal
- World Health Organisation international non-proprietary name
- flutrimazole
- Commons category
- Flutrimazole
- inhibitor of
- growth
- medical condition treated
- fungal infectious disease
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Mechanism of action
- See also
- References
Flutrimazole is a wide-spectrum antifungal drug. It is used for the topical treatment of superficial mycoses of the skin. Flutrimazole is an imidazole derivative. Its antifungal activity has been demonstrated in in vivo and in vitro studies to be comparable to that of clotrimazole and higher than bifonazole.
==Mechanism of action== It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol 14 α-demethylase.
Excerpted from Wikipedia’s “flutrimazole” article, available under the CC BY-SA 4.0 licence.
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