Structure via PubChem · Public domain (PubChem)
furafylline
Sign in to saveFurafylline is a methylxanthine derivative that was introduced in hope of being a long-acting replacement for theophylline in the treatment of asthma. It is an inhibitor of CYP1A2.
In the Vinony graph
Vinony's link graph records 95 inbound references to furafylline, and connects out to medication, asthma and respiratory system.
Vinony files it under 2-Furyl compounds, Chemical pages without DrugBank identifier and CYP1A2 inhibitors.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C12H12N4O3
- Molecular weight
- 260.25 g/mol
- IUPAC name
- 3-(furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione
- SMILES
- CC1=NC2=C(N1)C(=O)N(C(=O)N2CC3=CC=CO3)C
- InChIKey
- KGQZGCIVHYLPBH-UHFFFAOYSA-N
- XLogP
- 0.6
- Polar surface area
- 82.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
283 papers- Availability of furafylline.Pharmacogenetics · 1995
- Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.British journal of clinical pharmacology · 1990
- Characterization of the inhibition of P4501A2 by furafylline.Xenobiotica; the fate of foreign compounds in biological systems · 1994
- Accumulation of caffeine in healthy volunteers treated with furafylline.British journal of clinical pharmacology · 1987
- Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline.Chemical research in toxicology · 1993
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 260.090940244
Show 3 more facts
- chemical formula
- C₁₂H₁₂N₄O₃
- canonical SMILES
- Cc1[nH]c2c(n1)n(c(=O)n(c2=O)C)Cc3ccco3
- Commons category
- Furafylline
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Furafylline is a methylxanthine derivative that was introduced in hope of being a long-acting replacement for theophylline in the treatment of asthma. It is an inhibitor of CYP1A2.
==References==
Excerpted from Wikipedia’s “furafylline” article, available under the CC BY-SA 4.0 licence.