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GeneQ18030364· pop 6· linked from 813 articles

PBX2

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Also known as G17, HOX12, PBX2MHC, PBX homeobox 2

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.

In the Vinony graph

Vinony's link graph records 813 inbound references to PBX2, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

Vinony files it under Genes on human chromosome 6 and Transcription factors.

Vinony links it to 6 Wikipedia language editions.

Gene data

PBX2

Name: PBX homeobox 2
Type: protein-coding
Position: 32,184,733–32,190,278 (−)
Aliases: G17, HOX12, PBX2MHC
Ensembl: ENSG00000232005
RefSeq RNA: NM_002586.5, XM_047418839.1, XM_054328504.1, XM_054329825.1, XM_054330606.1
RefSeq protein: NP_002577.2, XP_047274795.1, XP_054184479.1, XP_054185800.1, XP_054186581.1

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

eye development regulation of DNA-templated transcription brain development animal organ morphogenesis positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II embryonic organ development neuron development

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding chromatin binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm transcription regulator complex

via MyGene.info

Gene · Ensembl

PBX homeobox 2

Symbol: PBX2
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr HSCHR6_MHC_SSTO_CTG1:3,500,940-3,506,391
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: HoxB1-Pbx1 heterodimer binding DNA 1b72.png

Show 8 more facts

HomoloGene ID: 48115
genetic association: asthma
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5089
chromosome: human chromosome 6
genomic start: 32184733
genomic end: 32190202
cytogenetic location: 6p21.32

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
Interactions
References
Further reading
External links

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.

== Function ==

Excerpted from Wikipedia’s “PBX2” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 6 Transcription factors