GNGT2
Sign in to saveAlso known as G-GAMMA-8, G-GAMMA-C, GNG8, GNG9, GNGT8, G protein subunit gamma transducin 2, HG3I
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 is a signalling protein protein that in humans and vertebrates is encoded by the GNGT2 gene. Either GNGT1 or GNGT2 is the gamma subunit of the Gβγ part of transducin (written G(T) or Gt), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cell of the eye, where it is thought to play a crucial role in phototransduction. GNGT2 only occurs in cone cells, and GNGT1 only occurs in rod cells.
In the Vinony graph
Vinony's link graph records 88 inbound references to GNGT2, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 17.
Vinony links it to 6 Wikipedia language editions.
Gene data
GNGT2- Name
- G protein subunit gamma transducin 2
- Type
- protein-coding
- Position
- 49,202,791–49,210,610 (−)
- Aliases
- G-GAMMA-8, G-GAMMA-C, GNG9, GNGT8, HG3I
- Ensembl
- ENSG00000167083
- RefSeq RNA
- NM_001198754.2, NM_001198755.1, NM_001198756.1, NM_031498.2
- RefSeq protein
- NP_001185683.1, NP_001185684.1, NP_001185685.1, NP_113686.1
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
G protein subunit gamma transducin 2
- Symbol
- GNGT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:49,202,791-49,210,610
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 11325
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2793
- genomic end
- 47287936
- genomic start
- 47280153
- chromosome
- human chromosome 17
- cytogenetic location
- 17q21.32
- expressed in
- gallbladder
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 is a signalling protein protein that in humans and vertebrates is encoded by the GNGT2 gene. Either GNGT1 or GNGT2 is the gamma subunit of the Gβγ part of transducin (written G(T) or Gt), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cell of the eye, where it is thought to play a crucial role in phototransduction. GNGT2 only occurs in cone cells, and GNGT1 only occurs in rod cells.
As the gamma subunit (Gγ) of three different families of G proteins (G(I)/Gi, G(S)/Gs and G(O)Go), GNGT2 is expressed in at least 23 tissues and other cell types, including monocytes of the vertebrate innate immune system, where at increased levels it has been shown to be a potential prognostic marker for some types of cancer, including esophageal cancer.
Excerpted from Wikipedia’s “GNGT2” article, available under the CC BY-SA 4.0 licence.