Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 is a signalling protein protein that in humans and vertebrates is encoded by the GNGT2 gene. Either GNGT1 or GNGT2 is the gamma subunit of the Gβγ part of transducin (written G(T) or Gt), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cell of the eye, where it is thought to play a crucial role in phototransduction. GNGT2 only occurs in cone cells, and GNGT1 only occurs in rod cells.
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010].
via MyGene.info
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 is a signalling protein protein that in humans and vertebrates is encoded by the GNGT2 gene. Either GNGT1 or GNGT2 is the gamma subunit of the Gβγ part of transducin (written G(T) or Gt), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cell of the eye, where it is thought to play a crucial role in phototransduction. GNGT2 only occurs in cone cells, and GNGT1 only occurs in rod cells.
As the gamma subunit (Gγ) of three different families of G proteins (G(I)/Gi, G(S)/Gs and G(O)Go), GNGT2 is expressed in at least 23 tissues and other cell types, including monocytes of the vertebrate innate immune system, where at increased levels it has been shown to be a potential prognostic marker for some types of cancer, including esophageal cancer.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).