Hepzidine (INN) is a tricyclic antidepressant which was never marketed. It was first described by 1966. ==Synthesis== The synthesis has been described in the chemical literature: 700px|center| The reduction of dibenzosuberone (1) gives dibenzosuberol [1210-34-0] (2). This alcohol forms ethers exceedingly easily, probably via the carbonium ion. Treatment with N-methyl-4-piperidinol [106-52-5] (3) in the presence of acid gives hepzidine (4).
Hepzidine (INN) is a tricyclic antidepressant which was never marketed. It was first described by 1966. ==Synthesis== The synthesis has been described in the chemical literature: 700px|center| The reduction of dibenzosuberone (1) gives dibenzosuberol [1210-34-0] (2). This alcohol forms ethers exceedingly easily, probably via the carbonium ion. Treatment with N-methyl-4-piperidinol [106-52-5] (3) in the presence of acid gives hepzidine (4).
==See also== Diphenylpyraline is selfsame but is based on a benzhydrol aromatic pharmacophore. Dibenzosuberol is also used in the synthesis of Deptramine (DPH analog) as well as Oxitriptyline & Deptropine.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).