monatepil

Chemical data

Formula

C28H30FN3OS

Molecular weight

475.6 g/mol

IUPAC name

N-(6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-4-[4-(4-fluorophenyl)piperazin-1-yl]butanamide

SMILES

C1CN(CCN1CCCC(=O)NC2C3=CC=CC=C3CSC4=CC=CC=C24)C5=CC=C(C=C5)F

InChIKey

WFNRNNUZFPVBSM-UHFFFAOYSA-N

XLogP

4.8

Polar surface area

60.9 Ų

H-bond donors

1

H-bond acceptors

5

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 2

Molecule type

Small molecule

via ChEMBL · EBI

• Antihypertensive, antiatherosclerotic, and plasma lipid-lowering effects of monatepil, a novel calcium antagonist with alpha 1-adrenoceptor-blocking activity in experimental animals.American journal of hypertension · 1994
• Newer antihypertensive drugs.Current opinion in cardiology · 1995
• Effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic blocking activity, on the low-density lipoprotein receptor in human skin fibroblasts.Cardiovascular drugs and therapy · 1997
• Inhibitory effect of monatepil maleate on acyl-CoA:cholesterol acyltransferase activity in the liver of cholesterol-fed Japanese monkeys.American journal of hypertension · 1997
• Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits.Japanese journal of pharmacology · 1998

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

475.209

via Wikidata · CC0