HLA-E

Name

major histocompatibility complex, class I, E

Type

protein-coding

Position

30,489,495–30,494,205 (+)

Aliases

HLA-6.2, QA1

Ensembl

ENSG00000229252

RefSeq RNA

NM_005516.6, XM_017010807.2, XM_054329806.1, XM_054330294.1, XM_054330589.1

RefSeq protein

NP_005507.3, XP_016866296.1, XP_054185781.1, XP_054186269.1, XP_054186564.1

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

major histocompatibility complex, class I, E

Symbol

HLA-E

Biotype

Protein coding

Organism

Homo sapiens

Location

6:30,489,495-30,494,205

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

HLA-E.png

via Wikidata · CC0