Structure via PubChem · Public domain (PubChem)
indorenate
Sign in to saveIndorenate (TR-3369), is a tryptamine derivative which acts as an agonist at the 5-HT1A, 5-HT1B and 5-HT2C serotonin receptors. It has anxiolytic, antihypertensive and anorectic effects, predominantly through action at 5-HT1A, but with some contribution from the 5-HT1B and 5-HT2C subtypes, and possibly some other non-serotonergic targets also.
Chemical data
- Formula
- C13H16N2O3
- Molecular weight
- 248.28 g/mol
- IUPAC name
- methyl 3-amino-2-(5-methoxy-1H-indol-3-yl)propanoate
- SMILES
- COC1=CC2=C(C=C1)NC=C2C(CN)C(=O)OC
- InChIKey
- YFEDJMLMWJSRJJ-UHFFFAOYSA-N
- XLogP
- 0.9
- Polar surface area
- 77.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
59 papers- Indorenate modifies a1-adrenergic and benzodiazepine receptor binding in the rat brain: an autoradiography study.The Journal of pharmacy and pharmacology · 2006
- Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors.Psychopharmacology · 2002
- Indorenate improves motor function in rats with chronic spinal cord injury.Basic & clinical pharmacology & toxicology · 2007
- Discriminative stimulus properties of indorenate, a serotonin agonist.Journal of psychiatry & neuroscience : JPN · 1999
- New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: in vivo and in silico studies.Canadian journal of physiology and pharmacology · 2026
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 248.116
Show 4 more facts
- subject has role
- serotonin receptor agonists
- chemical formula
- C₁₃H₁₆N₂O₃
- canonical SMILES
- COC1=CC2=C(C=C1)NC=C2C(CN)C(=O)OC
- Commons category
- Indorenate
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Indorenate (TR-3369), is a tryptamine derivative which acts as an agonist at the 5-HT1A, 5-HT1B and 5-HT2C serotonin receptors. It has anxiolytic, antihypertensive and anorectic effects, predominantly through action at 5-HT1A, but with some contribution from the 5-HT1B and 5-HT2C subtypes, and possibly some other non-serotonergic targets also.
== See also == 5-Methoxytryptamine Acetryptine
Excerpted from Wikipedia’s “indorenate” article, available under the CC BY-SA 4.0 licence.