IRS2
Sign in to saveAlso known as IRS-2, insulin receptor substrate 2
protein-coding gene in the species Homo sapiens
In the Vinony graph
Within Vinony's link graph, IRS2 is referenced by 16 other articles, and connects out to PubMed, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 13.
Its subject is documented across 5 Wikipedia language editions.
Gene data
IRS2- Name
- insulin receptor substrate 2
- Type
- protein-coding
- Position
- 109,752,695–109,786,634 (−)
- Aliases
- IRS-2
- Ensembl
- ENSG00000185950
- RefSeq RNA
- NM_003749.3
- RefSeq protein
- NP_003740.2
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
insulin receptor substrate 2
- Symbol
- IRS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 13:109,752,695-109,786,634
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein IRS2 PDB 3FQW.png
Show 8 more facts
- HomoloGene ID
- 2778
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8660
- genomic end
- 109786583
- genomic start
- 109752695
- expressed in
- middle temporal gyrus
- chromosome
- human chromosome 13
- cytogenetic location
- 13q34
via Wikidata · CC0