-Lercanidipin%20Structural%20Formula%20V1.svg)
lercanidipine
Lercanidipine (INN) is an antihypertensive (blood pressure lowering) drug. It belongs to the dihydropyridine class of calcium channel blockers, which work by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. This lowers the blood pressure and allows the heart to work more efficiently.
Key facts
- Drug.verifiedrevid
- 408573138
- Drug.IUPAC_name
- (RS)-2[(3,3-Diphenylpropyl)(methyl)amino]-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Drug.image
- Lercanidipine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.tradename
- Zanidip, Leridip
- Drug.pregnancy_category
- C (no data in humans)
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- Oral
- Drug.bioavailability
- ~10% (due to first-pass effect)
- Drug.protein_bound
- >98%
- Drug.metabolism
- Mainly CYP3A4
Article
13 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- Detection in body fluids
- References
- Further reading
- External links
Lercanidipine (INN) is an antihypertensive (blood pressure lowering) drug. It belongs to the dihydropyridine class of calcium channel blockers, which work by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. This lowers the blood pressure and allows the heart to work more efficiently.
This drug (trade name Zanidip, among others) acts more slowly than older dihydropyridines. It probably has fewer adverse effects, but a comparatively high potential for drug interactions.